9/19/2023 0 Comments Axograph xIntertwined with this role is the importance of the amygdala in social behavior. The amygdala has a prominent role in mood and emotion. This pathophysiology may contribute to the disruption of social behavior after developmental social deprivation, and may be a novel target to facilitate the treatment of social disorders. These results demonstrate discrete, subnucleus-specific effects of social deprivation on the physiology of MeAp neurons. In vitro electrophysiological studies found that postweaning social isolation caused a presynaptic impairment of excitatory input to the dorsal MeAp, but a progressive postsynaptic reduction of membrane excitability in the ventral MeAp. We found that postweaning social isolation caused a decrease of in vivo firing activity of MeAp neurons, and reduced drive from excitatory afferents. In this study, we tested whether postweaning social isolation caused abnormal activity of MeA neurons. However, little is known about the effects of social isolation on the function of MeA neurons. In rodents, postweaning social isolation causes a range of deficits in sexual and agonistic behaviors that normally rely on the posterior MeA (MeAp). As such, the normal development of this region may be disrupted by social deprivation. The medial nucleus of the amygdala (MeA) is a key region for performance of social behaviors and still undergoes maturation during the periadolescent period. There is also evidence that prepubertal neglect in children causes abnormal metabolic activity in several brain regions, including the amygdala area. Children exposed to neglect or social deprivation are at heightened risk for psychiatric disorders and abnormal social patterns as adults.
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